Hedgehog

Somatic Chromosomes of Long-Eared Desert Hedgehog Hemiechinus auritus

Hedgehog hives.

BACKGROUND Hedgehogs are increasingly popular pets in the United States and Europe. A number of infections may be acquired from these animals, and hedgehogs are possible hosts of parasites. However, to our knowledge there arc no previous reports of urticarial reactions to hedgehogs. OBSERVATIONS We describe 3 patients who developed an acute, transient, urticarial reaction after contact with t...

Hedgehog signaling.

The Hedgehog (Hh) proteins belong to one of a small number of families of secreted signals that play a central role in the development of most metazoans. hh itself was originally identified as a mutation that causes a “segment polarity” phenotype in Drosophila—as were most of the core components of the Hh signal transduction pathway (Ingham et al. 2011). These components have been highly conser...

Agonizing Hedgehog

program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-Kamenetsky and colleagues in this issue of the Journal of Biology [1] presents a compelling example of how the search for therapeutics can provide powerful experimental tools and insights into fundamental biology, blurring the distinction between applied and basic research. By ch...

Hedgehog signalling

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...